What Sky lacks in flavour profile, it makes up for in quick-acting cerebral effects. Users can become more acutely perceptive of their surroundings, tuned into sounds and patterns that may have gone unnoticed before. Enthusiasts also describe an almost immediate uplift in mood and an energy and focus that can applied to either mundane tasks like cleaning or more complex problem-solving processes. Sky can also be creatively valuable, inducing a kind of rapid-fire thought association that can open up some previously unexplored territory.

Psychedelic effects like visual distortion and increased perception can amplify the impact of music or art, while a very mild body buzz mellows users out. Because of its deeply cerebral effects, this strain is typically more psychologically than physically helpful. It can aid those with attention deficit disorders in sustaining focus on a single topic. It can also boost energy in cases of fatigue or depression. Some users have even described Sky as efficient in relieving migraines.